PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion
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- 作者：Roberto Tinoco1 ; 2 ; Florent Carrette1 ; Monique L. Barraza1 ; Dennis C. Otero1 ; Jonathan Magañ ; a1 ; Marcus W. Bosenberg3 ; Susan L. Swain4 ; Linda M. Bradley1 ; lbradley@sbpdiscovery.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：lymphocytic choriomeningitis virus clone 13 ; P-selectin glycoprotein ligand-1 ; programmed death-1 ; T cell exhaustion ; immunopathology ; inhibitory receptors ; melanoma ; cancer
- 刊名：Immunity
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：44
- 期：5
- 页码：1190-1203
- 全文大小：1903 K
文摘
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T cell survival was increased in Selplg−/− mice after chronic virus infection
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Multi-functional anti-viral T cells in Selplg−/− mice promoted viral control
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Ligating PSGL-1 on exhausted CD8+ T cells silenced TCR signals
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PSGL-1-deficiency enhanced T cell anti-tumor immunity to melanoma