Pregnane glycosides from the antidepressant active fraction of cultivated Cynanchum otophyllum

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• 作者：Xin Li^a ; Yang Luo^b ; Gan-Peng Li^b ; Qing-Xiong Yang^a ; ^{yangqx@gznu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cynanchum otophyllum ; Pregnane glycosides ; Cynanotophylloside ; Antidepressant
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：110
• 期：Complete
• 页码：96-102
• 全文大小：322 K

文摘

Based on the bioactive screening results, four new pregnane glycosides, namely cynanotophyllosides A–D (1–4) were isolated from the anti-depressant active fraction of cultivated Cynanchum otophyllum, along with thirteen known compounds (5–17). The new compounds were characterized as qingyangshengenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (1), qingyangshengenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-α-L-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (2), caudatin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-thevetopyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-digitoxopyranoside (3) caudatin-3-O-β-D-glucopyranosyl -(1 → 4)-β-D-thevetopyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (4), by detailed spectroscopic analysis and acidic hydrolysis.