Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

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• 作者：Nicolas Snaidero¹ ; ² ; ⁹ ; Caroline Velte¹ ; ⁹ ; Matti Myllykoski³ ; Arne Raasakka³ ; ⁴ ; Alexander Ignatev³ ; Hauke B. Werner⁵ ; Michelle S. Erwig⁵ ; Wiebke M&ouml ; bius⁵ ; ⁶ ; Petri Kursula³ ; ⁴ ; Klaus-Armin Nave⁵ ; ⁶ ; Mikael Simons¹ ; ² ; ⁷ ; ⁸ ; ¹⁰ ; ^{msimons@gwdg.de}
• 关键词：myelin ; oligodendrocytes ; glia ; axons ; neurodegeneration ; CNP ; MBP ; demyelinating diseases
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：314-323
• 全文大小：4075 K
• 卷排序：18

文摘

Characterization of “cytoplasmic channels” in myelin close to their native state Antagonistic functions of MBP and CNP in generating cytoplasmic channels CNP interacts with and bundles actin Reducing MBP levels rescues axonal pathology in CNP-deficient mice