148 Prevalence of chronic rhinosinusitis and upper airways colonisation in the Welsh adult cystic fibrosis population

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• 作者：R. Mills-Bennett ; V. Angulatta ; S. Thomas ; J. Duckers
• 刊名：Journal of Cystic Fibrosis
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：14
• 期：supp_S1
• 页码：S96
• 全文大小：60 K

文摘

Symptoms of chronic rhinosinusitis (CRS) have been reported in 11–94% of CF patients. Upper airways (UAW) infection with Psa (evaluated by nasal lavage) has been suggested as a potential reservoir for infection of the lower airways (LAW) (Mainz 2009). CF lung transplant recipients become re-colonised with the same bacteria as those cultured before transplant (Walter 1997). It is likely that this occurs from a bacterial reservoir in the paranasal sinuses (Johansen 2012).

Aim

20">To assess the prevalence of CRS symptoms in adults attending the AWACFC as measured by the Sino-Nasal Outcome Test: SNOT-22. To assess the prevalence bacterial isolates from the UAW in our population on nasal lavage.

Method

All patients completed a SNOT22 at annual review. UAW samples using nasal lavage were taken from patients scoring >30 on SNOT22 or post lung transplant patients.

Results

219 patients (128 males, mean FEV₁ 67.9%) completed the SNOT-22 of which 43 (20%) scored >30 (suggestive of CRS). 15 patients were post lung transplant of whom 10 (67%) scored >30. Of the patients who were sampled; 19 had Psa (3 post transplant), 18 patients had no growth, 9 Staphylococcus aureus (4 post transplant), 1 Burkholderia multivorans, 1 Pseudomonas fluorescens (post Tx), 1 Klebsiella pneumoniae, 1 Enterobacter. All patients who isolated Psa in the UAW isolated Psa in their LAW.

Conclusion

The prevalence of Psa in the UAW of our population is less than previously reported (Johansen 2012 (78%), this may be due to the sampling technique, however the UAW and LAW presence of Psa is in keeping with previous studies (Mainz et al. 2009) which suggest the sinuses may be a reservoir for the LAW.