Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation
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- 作者：Qi Zhanga ; Jie Duana ; Xishi Liua ; b ; Sun-Wei Guoa ; b ; hoxa10@outlook.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endometriosis ; Epithelial-mesenchymal transition ; Fibroblast-to-myofibroblast transdifferentiation ; Fibrosis ; Platelet ; Smooth muscle metaplasia
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：428
- 期：Complete
- 页码：1-16
- 全文大小：3912 K
文摘
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Platelets activate the TGF-β/Smad signaling pathway in endometriosis.
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Platelets induce epithelial–mesenchymal transition in endometriotic epithelial cells.
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Platelets induce myofibroblast activation in endometriotic stromal cells.
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Platelets enhance cell contractility and collagen production in endometriotic cells.
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Platelets promote smooth muscle metaplasia and fibrosis in endometriosis.