Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers
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- 作者：Irina V. Proninaa ; 1 ; Vitaly I. Loginova ; 1 ; Alexey M. Burdennyya ; Marina V. Fridmana ; Tatiana P. Kazubskayab ; Alexey A. Dmitrievc ; Eleonora A. Bragaa ; eleonora10_45@mail.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：miRNA ; microRNA ; mRNA ; messenger RNA ; BC ; breast cancer ; OC ; ovarian cancer ; RT-PCR ; reverse transcription PCR ; qPCR ; quantitative PCR ; rs ; Spearman's correlation coefficient ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; FDR ; false discovery rate ; MSP ; methylation specific PCR ; ld ; low differentiated ; md ; moderately differentiated ; hd ; high differentiated ; GO ; Gene Ontology
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：483-491
- 全文大小：871 K
文摘
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The hypermethylation of SEMA3B and MIR-129-2 genes was revealed in BC and/or OC.
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SEMA3B and MIR-129-2 hypermethylation correlated with their down-regulation in BC.
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RASSF1(A), GPX1 level correlated with miR-129-2 precursor level and methylation in BC.
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RASSF1(A) and mature miR-129-2 expression levels correlated negatively in BC.
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Cross-talk of DNA methylation and microRNA impacts on gene expression revealed in BC.