Latent TGF-β binding protein-1 deficiency decreases female fertility

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• 作者：Eileen Dietzel^a ; ^{eileen.dietzel@rwth-aachen.de} ; Sabine Weiskirchen^b ; Julia Floehr^a ; Masahito Horiguchi^c ; Vesna Todorovic^c ; ^d ; Daniel B. Rifkin^c ; ^d ; Willi Jahnen-Dechent^a ; Ralf Weiskirchen^b ; ^{rweiskirchen@ukaachen.de}
• 关键词：Transforming growth factor-β ; Latent binding protein ; Female infertility ; Ovarian cyst ; Puberty
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1387-1392
• 全文大小：1380 K
• 卷排序：482

文摘

Ltbp1ΔEx5 females show impaired fertility associated with delayed sexual maturity. Ltbp1ΔEx5 females are prone to ovarian cyst formation. Respective mice have lowered estrogen and progesterone serum levels. LTBP1 is an essential component in the network regulating female fertility.