Estrogen modulates neural-immune interactions through intracellular signaling pathways and antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats

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• 作者：Prathamesh Kale ; Aparna Mohanty ; Anushree Patil ; Miti Mishra ; Uday P. Pratap ; Hannah P. Priyanka ; Srinivasan ThyagaRajan
• 关键词：Cytokine ; Tyrosine hydroxylase ; Nerve growth factor ; ERK ; CREB ; Akt
• 刊名：Journal of Neuroimmunology
• 出版年：15 February, 2014
• 年：2014
• 卷：267
• 期：1-2
• 页码：7-15
• 全文大小：1780 K

文摘

Modulation of neural-immune interactions by estrogen in the spleens of ovariectomized (OVX) middle-aged female rats was examined. Con A-induced lymphoproliferation, splenic tyrosine hydroxylase (TH) and nerve growth factor (NGF) expression, levels of p-ERK 1/2, p-CREB, and p-Akt, and activity of superoxide dismutase decreased in OVX rats while estrogen treatment enhanced their expression, levels, and activity. Also, estrogen treatment enhanced Con A-induced IFN-纬 production and decreased Con A-induced IL-2 production compared to OVX animals. In contrast, estrogen increased the extent of lipid peroxidation and protein carbonyl formation while OVX induced a decline in protein carbonyl formation. These results suggest that estrogen enhances neural-immune interactions while simultaneously affecting it through generation of free radicals as reflected by increased lipid peroxidation and protein carbonyl formation.