文摘
Acute oxidative stress increased intracellular ROS, caused DNA oxidation and damage. Oxidation induced LaRPA-1 dissociation from the 3′ G-overhang and telomere shortening. LaRPA-1 act as a SSB protecting the C-rich single-strand telomeric gaps generated upon oxidation. Oxidation caused death in part of the population and cell-cycle arrest in the survivors. Survivors continued replicating DNA, were more resistant to H2O2 and recovered telomere length.