The study included 2254 patients who were followed up for 4 years. Obesity was classified as a body mass index 鈮?0 and overweight as a body mass index of 25.0-29.9. Central obesity was defined as waist circumference 鈮?8 cm for women and 鈮?02 cm for men. Independent predictors of total and cardiac mortality were assessed in a multivariate Cox model adjusted for confounding variables.
Obesity was present in 35% of patients, overweight in 43%, and central obesity in 60%. Body mass index and waist circumference were independent predictors of lower total mortality: hazard ratio =0.84 (P<.001) and hazard ratio = 0.97 (P=.01), respectively, and lower cardiac death (body mass index, hazard ratio =0.84, P<.001; waist circumference, hazard ratio =0.97, P=.01). The interaction between body mass index and waist circumference (hazard ratio =1.001, P<.01) showed that the protective effect of body mass index was lost in patients with a waist circumference >120 cm.
Mortality was significantly lower in patients with a high body mass index and waist circumference. The results also showed that this protection was lost when these indicators over a certain limit.