Factors associated with adipocyte size reduction after weight loss interventions for overweight and obesity: a systematic review and meta-regression

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• 作者：Jessica Murphy^a ; ^b ; ^c ; Gré ; gory Moullec^c ; ^d ; Sylvia Santosa^a ; ^b ; ^c ; ^{s.santosa@concordia.ca}
• 关键词：Obesity ; Adipocyte size ; Adipose tissue dysfunction ; Weight loss
• 刊名：Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：31-40
• 全文大小：847 K
• 卷排序：67

文摘

Enlarged adipocytes are a prime feature of adipose tissue dysfunction, and may be an appropriate target to decrease disease risk in obesity. We aimed to assess the change in adipocyte size in response to lifestyle and surgical weight loss interventions for overweight or obesity; and to explore whether certain participant and intervention characteristics influence this response.MethodsWe systematically searched MEDLINE, EMBASE, CINAHL and Cochrane electronic databases to identify weight loss studies that quantified adipocyte size before and after the intervention. Using meta-regression analysis, we assessed the independent effects of weight loss, age, sex, adipocyte region, and intervention type (surgical vs. lifestyle) on adipocyte size reduction. We repeated the model as a sensitivity analysis including only the lifestyle interventions.ResultsThirty-five studies met our eligibility criteria. In our main model, every 1.0% weight loss was associated with a 0.64% reduction in adipocyte size (p = 0.003); and adipocytes from the upper body decreased 5% more in size than those in the lower body (p = 0.009). These relationships were no longer significant when focusing only on lifestyle interventions. Moreover, age, sex and intervention type did not independently affect adipocyte size reduction in either model.ConclusionsWeight loss in obese individuals is consistently associated with a decrease in adipocyte size that is more pronounced in upper-body adipocytes. It remains to be clarified how biological differences and intervention characteristics influence this relationship, and whether it corresponds with reductions in other aspects of adipose tissue dysfunction and disease risk.