Fasting Triglycerides and Glucose Index as a Diagnostic Test for Insulin Resistance in Young Adults

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• 作者：Fernando Guerrero-Romero^a ; Rafael Villalobos-Molina^b ; J. Rafael Jimé ; nez-Flores^b ; Luis E. Simental-Mendia^a ; René ; Mé ; ndez-Cruz^b ; Miguel Murguí ; a-Romero^b ; Martha Rodrí ; guez-Morá ; n^a ; ^{rodriguez.moran.martha@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Triglycerides and glucose index ; Insulin resistance ; Young adults ; Triglycerides
• 刊名：Archives of Medical Research
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：47
• 期：5
• 页码：382-387
• 全文大小：252 K

文摘

Although the Glucose and Triglyceride levels (TyG) index is useful for identification of insulin resistance (IR) in different ethnic groups, it has not been evaluated in young adults. We undertook this study to evaluate the TyG index as a diagnostic test for IR in young adults.

Methods

A total of 5,538 healthy young adults, 3,795 (68.5%) non-pregnant women and 1,743 (31.5%) men, with an average age of 19.2 ± 1.4 years, were enrolled in a population-based cross-sectional study. To estimate diagnostic characteristics of the TyG index, a randomized subsample of the target population (n = 75) was under euglycemic-hyperinsulinemic clamp test. Using the cutoff values obtained in the clamp study, the diagnostic concordance between TyG index and HOMA-IR was evaluated in the overall population. The TyG index was calculated as the Ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2.

Results

Normal weight, overweight, and obesity were identified in 3,632 (65.6%), 1,355 (24.5%), and 551 (9.9%) participants. A total of 346 (9.1%) men and 278 (15.9%) women exhibited IR. The best cutoff value of TyG index for diagnosis of IR was 4.55 (sensitivity 0.687, negative predictive value (NPV) 0.844, and negative likelihood ratio (NLR) 0.47) for women and 4.68 (sensitivity 0.673, NPV 0.900, and NLR 0.45) for men. In normal-weight individuals the diagnostic concordance between TyG index and HOMA-IR was 0.934 and 0.915, in the overweight subjects was 0.908 and 0.895 and, in the obese participants 0.916 and 0.950, for men and women, respectively.

Conclusions

TyG index may be useful for screening IR in young adults.