CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes

详细信息    查看全文

• 作者：Bartosz Słomiński^a ; ^{bartosz@gumed.edu.pl} ; Urszula Ławrynowicz^a ; Jolanta Myśliwska^a ; Monika Ryba-Stanisławowska^a ; Maria Skrzypkowska^a ; Agnieszka Brandt^b
• 关键词：Diabetes retinopathy ; CCR5-Δ 32 polymorphism ; Inflammation
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：256-260
• 全文大小：228 K
• 卷排序：439

文摘

We analyzed the CCR5-Δ32 polymorphism in patients with type 1 diabetes. We found significant negative association between type 1 diabetes and Δ32 allele. The frequency of Δ32 allele was the highest in a group with retinopathy. Δ32 carriers had higher levels of: HbA1c, inflammatory markers and adhesion molecules. The Δ32 allele increases the risk of diabetic retinopathy.