Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans
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- 作者：Rossio K. Kersey ; Thomas M. Brodigan ; Tetsunari Fukushige ; Michael W. Krause ; michaelkr@niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Forkhead ; FOXD ; UNC-130 ; UNC-129 ; Embryogenesis ; Transcriptional regulation
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：416
- 期：2
- 页码：300-311
- 全文大小：6309 K
文摘
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UNC-130/FOXD establishes, but does not maintain, a muscle gradient of UNC-129/TGF-β.
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Expression of unc-130 and unc-129 are mutually exclusive in wild type muscle cells.
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Low levels of UNC-130/FOXD are sufficient to prevent unc-129 expression in muscle.
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Muscle activation of unc-130 depends on proper cell migration.
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Multiple Forkhead factors act redundantly to fine-tune unc-129 and unc-130 expression.