The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice
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- 作者：Ameh Omedea ; Min Zia ; Sukhpal Prehara ; Arfa Maqsooda ; Nicholas Stafforda ; Mamas Mamasb ; Elizabeth Cartwrighta ; Delvac Oceandya ; delvac.oceandy@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：GPCRs ; OXGR1 ; Cardiac hypertrophy ; Pressure overload ; STAT3
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：479
- 期：4
- 页码：708-714
- 全文大小：1400 K
文摘
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Genetic ablation of OXGR1 led to the increase in cardiac hypertrophy following pressure overload.
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OXGR1 interacts with CSN5 in cardiomyocytes.
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OXGR1 regulates STAT3 signalling pathway possibly through modulation of CSN5-TYK2 signalling complex.