Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1
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- 作者：Vladimir L. Kolossov ; viadimer@illinois.edu ; Nagendraprabhu Ponnuraj ; Jessica N. Beaudoin ; Matthew T. Leslie ; Paul J. Kenis ; H. Rex Gaskins
- 关键词：Redox homeostasis ; DNQ and β-lapachone ; NQO1 ; Lung and pancreatic cancer ; roGFP2 redox probe
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2017
- 出版时间：29 January 2017
- 年：2017
- 卷：483
- 期：1
- 页码：680-686
- 全文大小：1369 K
- 卷排序：483
文摘
Pharmacologic quinones elicit distinct compartmentalized oxidation of glutathione poise. Cytosolic oxidation is NQO1-dependent whereas mitochondrial is cell line dependent. High DNQ potency is result of its outstanding NQO1 substrate specificity. Low DNQ concentrations required for solid cancer treatments mitigate off target effects. β-lapachone at pharmacologic doses triggers oxidation of cysteines in normal cells.