Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose
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- 作者：John B. Hibbs Jr.a ; b ; john.hibbs@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author ; Zdenek Vavrinb ; James E. Coxc ; d
- 关键词：AUC ; area under the curve ; FGT ; female genital tract ; GC&ndash ; MS ; gas chromatography-mass spectrometry ; GSH ; reduced glutathione ; GSSG ; oxidized glutathione ; LC&ndash ; MS ; liquid chromatography&ndash ; mass spectrometry ; NET ; neutrophil extracellular trap ; NO ; nitric oxide ; NOB-PPP ; non-oxidative branch pentose phosphate pathway ; OB-PPP ; oxidative branch pentose phosphate pathway ; Pi ; inorganic phosphate ; PAP ; human prostate acid phosphatase ; PNP ; purine nucleoside phosphorylase ; PNCP ; purine nucl
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：8
- 期：Complete
- 页码：271-284
- 全文大小：3249 K
文摘
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Extracellular metabolism occurs in dilute human leukocyte cytosolic protein solution.
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Extracellular metabolism is activated by acid phosphatases.
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Ribose5P salvage from purine nucleotides and its metabolism produces NADPH.
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Extracellular NADPH generating metabolism influences the redox environment.
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Extracellular metabolism could be a component of inflammation and wound healing.