Transketolase: Observations in alcohol-related brain damage research

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• 作者：Kimberley Alex ; er-Kaufman ; Clive Harper
• 关键词：Transketolase ; Thiamine deficiency ; Alcohol-related brain ; Damage ; Wernicke-Korsakoffs’ ; Syndrome ; Neuropathology
• 刊名：The International Journal of Biochemistry and Cell Biology
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：41
• 期：4
• 页码：717-720
• 全文大小：333 K

文摘

Thiamin, or vitamin B1, is crucial for brain function. In its active form, thiamin pyrophosphate (TPP), it is a co-enzyme for several enzymes, including transketolase. Transketolase is an important enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP), a pathway responsible for generating reducing equivalents, which is essential for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase also links the PPP to glycolysis, allowing a cell to adapt to a variety of energy needs, depending on its environment. Abnormal transketolase expression and/or activity have been implicated in a number of diseases where thiamin availability is low, including Wernicke-Korsakoff's Syndrome and alcoholism. Yet, the precise mechanism by which this enzyme is involved in the pathophysiology of these disorders remains controversial.