Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity
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- 作者：Young-Jung Kim1 ; Tae-Won Kim1 ; So-Ra Park ; Hyun-Tae Kim ; Da-Young Jung ; Si-Yun Ryu ; Ju-Young Jung ; jyjung@cnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AKI ; acute kidney injury ; ATM ; ataxia telangiectasia mutated ; DSBs ; double-strand breaks ; MRN ; Mre11 ; Rad50 ; and Nbs1 ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; NAD ; nicotinamide adenine dinucleotide ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; PARP1 ; poly[ADP-ribose] polymerase 1 ; ROS ; reactive oxygen species ; Sirt1 ; sirtuin1
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：22-30
- 全文大小：2411 K
文摘
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MRN complex proteins and NQO1 were induced by cisplatin nephrotoxicity.
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10">Cisplatin-induced MRN complex protein expression decreased in NQO1-knockdown cells.
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15">Severe renal damage by cisplatin was followed by reduced MRN complex in NQO1−/− mice.
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Cisplatin-injected NQO1−/− mice showed disrupted DNA damage repair-related proteins.
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Reduced MRN complex might be related to the aggravated renal damage in NQO1−/− mice.