Bovine serum albumin binding, antioxidant and anticancer properties of an oxidovanadium(IV) complex with luteolin
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- 作者：Luciana G. Nasoa ; Luis Lezamab ; c ; Marí ; a Valcarceld ; Clarisa Saladod ; Patricia Villacé ; d ; Danel Kortazard ; Evelina G. Ferrera ; Patricia A.M. Williamsa ; williams@quimica.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：Luteolin ; Oxidovanadium(IV) complexes ; Magnetic properties ; Mechanisms of cytotoxic action ; BSA binding
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：80-93
- 全文大小：1923 K
文摘
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Luteolin coordinated to oxidovanadium(IV) through cis diol-O atoms.
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The CO and 5-OH groups of the flavonoid remained uncoordinated.
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The antioxidant effects of the ligand and the complex were similar.
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Promising agent against lung (A549) and breast (MDAMB231) tumor cells
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Protein binding studies confirmed the interactions of the complex with BSA.