Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy
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- 作者：Aaron R. Switzera ; d ; e ; Cheryl McCrearyb ; e ; Saima Batoolc ; e ; Randall B. Staffordc ; e ; Richard Fraynea ; e ; Bradley G. Goodyeara ; e ; Eric E. Smitha ; e ; eesmith@ucalgary.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：BOLD ; blood oxygenation level dependent ; CAA ; cerebral amyloid angiopathy ; fMRI ; functional magnetic resonance imaging ; FLAIR ; fluid attenuated inversion recovery ; ICH ; intracerebral hemorrhages ; SWI ; susceptibility-weighted imaging ; WMH ; white matter hyperintensity
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：461-467
- 全文大小：812 K
文摘
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Visual fMRI was performed in CAA and controls at baseline and at one year.
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BOLD response amplitude was lower at one year compared to baseline in CAA.
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BOLD response amplitude decreases were not seen in similarly-aged controls.
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Progressive impairment in vascular reactivity may be a feature of CAA.
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Decreased BOLD response amplitude was unrelated to other CAA-related vascular changes.