Lamina-dependent calibrated BOLD response in human primary motor cortex

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• 作者：Maria Guidi ; ^{guidi@cbs.mpg.de" class="auth_mail" title="E-mail the corresponding author} ; Laurentius Huber¹ ; Leonie Lampe ; Claudine J. Gauthier² ; Harald E. Mö ; ller ; ^{moeller@cbs.mpg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：dHb ; deoxyhemoglobin ; AAT ; arterial arrival time ; ASL ; arterial spin labeling ; BOLD ; blood-oxygen-level dependent ; SEM ; standard error of the mean ; CNR ; contrast-to-noise ratio ; CSF ; cerebrospinal fluid ; CV ; coefficient of variation ; EPI ; echo-planar imaging ; fMRI ; functional MRI ; FOV ; field of view ; GM ; gray matter ; GRE ; gradient-recalled echo ; M1 ; primary motor cortex ; MRI ; magnetic resonance imaging ; ROI ; region of interest ; S1 ; primary somatosensory cortex ; SD ; standard deviation ; SNR ; signa
• 刊名：NeuroImage
• 出版年：2016
• 出版时间：1 November 2016
• 年：2016
• 卷：141
• 期：Complete
• 页码：250-261
• 全文大小：2089 K

文摘

Disentangling neural activity at different cortical depths during a functional task has recently generated growing interest, since this would allow to separate feedforward and feedback activity. The majority of layer-dependent studies have, so far, relied on gradient-recalled echo (GRE) blood-oxygenation-level dependent (BOLD) acquisitions, which are weighted towards the large draining veins at the cortical surface. The current study aims to obtain quantitative brain activity responses in the primary motor cortex on a laminar scale without the contamination due to accompanying secondary vascular effects.

Evoked oxidative metabolism was evaluated using the Davis model, to investigate its applicability, advantages, and limits in lamina-dependent fMRI. Average values for the calibration parameter, M, and for changes in the cerebral metabolic rate of oxygen consumption (CMRO₂) during a unilateral finger-tapping task were (11 ± 2)% and (30 ± 7)%, respectively, with distinct variation features across the cortical depth. The results presented here showed an uncoupling between BOLD-based functional magnetic resonance imaging (fMRI) and metabolic changes across cortical depth, while the tight coupling between CMRO₂ and CBV was conserved across cortical layers.

We conclude that the Davis model can help to obtain estimates of lamina-dependent metabolic changes without contamination from large draining veins, with high consistency and reproducibility across participants.