Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death
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- 作者：Peng Zhaoa ; Ru Zhoua ; Hai-Ning Lib ; Wan-Xia Yaoa ; Hai-Qi Qiaoa ; Shu-Jing Wangc ; Yang Niud ; Tao Sune ; Yu-Xiang Lif ; Jian-Qiang Yua ; g ; yujq910315@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxymatrine ; Neuroprotection ; Hypoxic-ischemia ; Neonatal ; Cell death ; Antioxidant enzyme
- 刊名：Neurochemistry International
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：17-27
- 全文大小：4430 K
文摘
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Oxymatrine has shown neuroprotective effects on HIBD in neonatal rats.
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Oxymatrine improves antioxidant enzyme activities on HIBD in neonatal rats at 48 h.
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Oxymatrine increases the ratio of Bcl-2/Bax on HIBD in neonatal rats at 48 h.
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Oxymatrine decreased the expression of Caspase-3 on HIBD in neonatal rats at 48 h.
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Oxymatrine may have potential as neuroprotective agent for HIBD.