Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways
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- 作者：Hong-wei Zhaoa ; b ; 1 ; Zhen-fang Zhanga ; c ; 1 ; Xuan Chaia ; d ; Guang-quan Lia ; e ; He-rong Cuia ; c ; Hong-bo Wangf ; Ya-kun Menga ; b ; Hui-min Liua ; c ; Jia-bo Wanga ; Rui-sheng Lig ; Zhao-fang Baia ; baizf2008@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Xiao-he Xiaoa ; pharmacy302@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxymatrine ; Hepatic fibrosis ; Toll like receptor 4 ; HMGB1 ; Bambi
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：249-255
- 全文大小：1443 K
文摘
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Oxymatrine shows protective effect against CCl4-induced hepatic fibrosis.
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Oxymatrine prevents inflammatory cytokines expression and activation of TGF-β1 signaling pathway.
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Oxymatrine upregulates Bambi to reduce TGF-β1-mediated HSC activation.