Parameters indicative of persistence of valvular pathology at initial diagnosis in acute rheumatic carditis: the role of albumin and CD19 expression

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• 作者：Taliha Oner^a ; Rahmi Ozdemir^a ; ^{rahmiozdemir35@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Dildar Bahar Genc^b ; Mehmet Kucuk^a ; Cem Karadeniz^a ; Savas Demirpence^a ; Murat Muhtar Yilmazer^a ; Timur Mese^a ; Vedide Tavli^a ; Ferah Genel^c
• 关键词：Acute rheumatic carditis ; Albumin ; CD8 ; CD19 ; Lymphocyte subtypes
• 刊名：Jornal de Pediatria
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：581-587
• 全文大小：550 K

文摘

The aim of this study is to define the predictors of chronic carditis in patients with acute rheumatic carditis (ARC).

Methods

Patients diagnosed with ARC between May 2010 and May 2011 were included in the study. Echocardiography, electrocardiography, lymphocyte subset analysis, acute phase reactants, plasma albumin levels, and antistreptolysin-O (ASO) tests were performed at initial presentation. The echocardiographic assessments were repeated at the sixth month of follow-up. The patients were divided into two groups according to persistence of valvular pathology at 6th month as Group 1 and Group 2, and all clinical and laboratory parameters at admission were compared between two groups of valvular involvement.

Results

During the one-year study period, 22 patients had valvular disease. Seventeen (77.2%) patients showed regression in valvular pathology. An initial mild regurgitation disappeared in eight patients (36.3%). Among seven (31.8%) patients with moderate regurgitation initially, the regurgitation disappeared in three, and four patients improved to mild regurgitation. Two patients with a severe regurgitation initially improved to moderate regurgitation (9.1%). In five (22.8%) patients, the grade of regurgitation [moderate regurgitation in one (4.6%), and severe regurgitation in 4 (18.2%)] remained unchanged. The albumin level was significantly lower at diagnosis in Group 2 (2.6 ± 0.48 g/dL). Lymphocyte subset analysis showed a significant decrease in the CD8 percentage and a significant increase in CD19 percentage at diagnosis in Group 2 compared to Group 1.

Conclusion

The blood albumin level and the percentage of CD8 and CD19 (+) lymphocytes at diagnosis may help to predict chronic valvular disease risk in patients with acute rheumatic carditis.