Association of functional genetic variation in PP2A with prefrontal working memory processing
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- 作者：Antonio Rampinoa ; b ; Pasquale Di Carloa ; Leonardo Fazioa ; Gianluca Ursinic ; Giulio Pergolaa ; Caterina De Virgiliod ; Gemma Gadaletad ; Giulia Maria Giordanoe ; Alessandro Bertolinoa ; b ; Giuseppe Blasib ; blasi.seppe@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein phosphatase 2A ; D2 dopamine receptor ; Working memory ; Prefrontal cortex ; fMRI
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：125-130
- 全文大小：1003 K
文摘
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Rs959627, a SNP in PPP2R2B modulates postmortem prefrontal cortex gene expression.
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The same SNP affects prefrontal cortex function during Working Memory processing.
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Putative mechanism relies on modulation on D2 cAMP-independent dopamine signaling.