Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury
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- 作者：P. Swiatkowskia ; b ; &dagger ; ; M. Murugana ; &dagger ; ; U.B. Eyoa ; Y. Wangc ; S. Rangarajud ; S.B. Ohe ; L.-J. Wua ; lwu@dls.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-AP ; 4-aminopyridine ; ACSF ; artificial cerebrospinal fluid ; CNS ; central nervous system ; P2Y12 KO ; P2Y12R knockout ; P2Y12R ; P2Y12 receptors ; PI3K ; phosphoinositide 3-kinase ; PTX ; pertussis toxin ; TEA ; tetraethylammonium
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：24 March 2016
- 年：2016
- 卷：318
- 期：Complete
- 页码：22-33
- 全文大小：2743 K
文摘
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Microglial P2Y12 receptor mediates ATP/ADP/UDP-induced process chemotaxis and outward K currents.
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Microglial P2Y12 receptor is coupled to K channel via Gi/Go signaling.
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Microglial P2Y12 receptor-mediated K channel is sensitive to quinine and bupivacaine.
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Neuronal injury induces P2Y12 receptor-dependent K currents in microglia.