Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments
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- 作者：Rafael Di Marco Barros1 ; 2 ; 3 ; Natalie A. Roberts1 ; Robin J. Dart1 ; 2 ; 4 ; Pierre Vantourout2 ; Anett Jandke1 ; Oliver Nussbaumer2 ; Livija Deban1 ; Sara Cipolat1 ; Rosie Hart1 ; Maria Luisa Iannitto2 ; Adam Laing2 ; Bradley Spencer-Dene1 ; Philip East1 ; Deena Gibbons2 ; Peter M. Irving4 ; Pablo Pereira5 ; Ulrich Steinhoff6 ; Adrian Hayday1 ; 2 ; 7 ; adrian.hayday@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：22 September 2016
- 年：2016
- 卷：167
- 期：1
- 页码：203-218.e17
- 全文大小：8398 K
文摘
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Gut epithelial butyrophilin-like 1 (Btnl1) shapes the local γδ T cell compartment
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Other organ-specific epithelial Btnl genes select cognate γδ cells in other sites
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Btnl heteromers can specifically activate γδ T cells with cognate T cell receptors
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Human BTNL genes reveal a conserved biology of epithelial T cell regulation