Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: Impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of inoculation
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- 作者：Paul Lawrence ; Juan Pacheco ; Carolina Stenfeldt ; Jonathan Arzt ; Devendra K. Rai ; Elizabeth Rieder ; Elizabeth.Rieder@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Jumonji C-domain containing protein 6 (JMJD6) ; Foot-and-mouth disease virus (FMDV) ; FMDV third receptor ; Viral pathogenesis
- 刊名：Virology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：492
- 期：Complete
- 页码：108-117
- 全文大小：5728 K
文摘
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Knockdown of JMJD6 was demonstrated to impede the progression of infection in cell culture with a JMJD6-targeted mutant FMDV.
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Post-attachment entry pathway for JMJD6-targeted mutant FMDV was determined to be through clathrin-coated pit mediated endocytosis.
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JMJD6-targeted mutant FMDV exhibited similar pathogenesis as the parental virus by both aerosol and intraepithelial lingual inoculation.
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JMJD6-targeted mutant FMDV was detected exclusively in JMJD6-positive cells by immunohistochemistry while the parental virus was only seen partially localizing with JMJD6-positive cells.