- 作者：Mingyan Dai ; MD* ; &dagger ; ; &Dagger ; ; Mingwei Bao ; MD ; PhD* ; &dagger ; ; &Dagger ; ; Yijie Zhang ; MD* ; &dagger ; ; &Dagger ; ; Lilei Yu ; MD ; PhD* ; &dagger ; ; &Dagger ; ; Quan Cao ; MD* ; &dagger ; ; &Dagger ; ; Yanhong Tang ; MD ; PhD* ; &dagger ; ; &Dagger ; ; He Huang ; MD ; PhD* ; &dagger ; ; &Dagger ; ; Xi Wang ; MD ; PhD* ; &dagger ; ; &Dagger ; ; Dan Hu ; MD ; PhD ; FHRS ; FAHA* ; &dagger ; ; &Dagger ; ; § ; ; Congxin Huang ; MD ; PhD ; FHRS ; FACC ; FESC* ; &dagger ; ; &Dagger ; ; huangcongxin@vip.163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Low-level carotid baroreflex stimulation ; Atrial fibrillation ; Left stellate ganglion ; Autonomic remodeling ; Autonomic nervous system
- 刊名：Heart Rhythm
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：13
- 期：11
- 页码：2203-2212
- 全文大小：8203 K
Objective
The purpose of this study was to investigate effects of short-term LL-CBS on an atrial fibrillation (AF) canine model.
Methods
Group 1 (LL-CBS in the 6 hour-rapid atrial pacing model): Anesthetized dogs underwent 6 hours of rapid atrial pacing (RAP) with concomitant LL-CBS in last 3 hours (LL-CBS group; n = 7) or without (control group; n = 6). Effective refractory period (ERP), ERP dispersion, and window of vulnerability to AF were determined. Left stellate ganglion (LSG) neural activity and heart rate variability were analyzed. Group 2 (LL-CBS on electrically or mechanically induced AF with acetylcholine): In subgroup 1, sustained AF was induced by injecting acetylcholine (Ach; 10 mM) into the anterior right ganglionated plexus at baseline and after 3-hour LL-CBS (n = 7) or sham operation (n = 6). In subgroup 2, Ach was applied onto the right atrial appendage. The time of duration of AF and the average AF cycle length were determined in both subgroups.
Results
Group 1: LL-CBS reversed the RAP-induced ERP shortening and increase in ERP dispersion and window of vulnerability (P < .05). The activation of LSG, decrease in high frequency, and increase in low frequency and low frequency/high frequency ratio induced by RAP were also reversed by LL-CBS (P < .05). After 6-hour RAP, plasma norepinephrine and angiotensin II concentrations were significantly lower in the LL-CBS group than in the control group (P < .05). Group 2: The AF duration was shortened and the average AF cycle length was prolonged markedly in both subgroups (P < .01) by LL-CBS.
Conclusion
LL-CBS can reverse RAP-induced atrial electrical remodeling and suppress electrically or mechanically induced AF with Ach, and the anti-AF effect is attributed to attenuation of autonomic nerve remodeling, including inhibition of the LSG activity.