Intrinsically disordered region of influenza A NP regulates viral genome packaging via interactions with viral RNA and host PI(4,5)P2
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- 作者：Michinori Kakisakaa ; Kazunori Yamadaa ; Akiko Yamaji-Hasegawab ; Toshihide Kobayashib ; Yoko Aidaa ; aida@riken.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：IAV ; NP ; vRNA ; PI(4 ; 5)P2 ; Genome packaging ; IDR
- 刊名：Virology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：496
- 期：Complete
- 页码：116-126
- 全文大小：6453 K
文摘
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NP IDR2 associates with viral RNA to construct the vRNP.
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NP IDR2 interacts with PI(4,5)P2 at the plasma membrane.
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These two functions facilitate viral genome packaging into the virion.