Alkynylation of halo pyrimidines under Pd/C–copper catalysis: regioselective synthesis of 4- and 5-alkynylpyrimidines

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• 作者：Manojit Pal ; Venkateswara Rao Batchu ; Nalivela Kumara Swamy and Srinivas Padakanti
• 关键词：4-Alkynyl-5-bromopyrimidine ; Palladium catalyst ; Terminal alkynes ; 5-Bromo-4-chloro-6-methylpyrimidine
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：5 June 2006
• 年：2006
• 卷：47
• 期：23
• 页码：3923-3928
• 全文大小：126 K

文摘

5-Bromo-4-chloro-6-methylpyrimidines underwent facile Pd/C–Cu catalyzed coupling reactions with a variety of terminal alkynes, which resulted in the corresponding 4-alkynyl-5-bromopyrimidines, regioselectively, with good yields. 4-Chloro-5-iodo-6-methylpyrimidine, however, yielded the corresponding 5-alkynyl-4-chloropyrimidines under the same reaction conditions.