Hypoxia-induced production of peptidylarginine deiminases and citrullinated proteins in malignant glioma cells

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• 作者：Taigen Sase^a ; ^b ; ^{sasetaigen@marianna-u.ac.jp} ; Mitsumi Arito^a ; ^{m-ari@marianna-u.ac.jp} ; Hidetaka Onodera^b ; ^{dera@marianna-u.ac.jp} ; Kazuki Omoteyama^a ; ^{omoteyama@marianna-u.ac.jp} ; Manae S. Kurokawa^c ; ^{manae@marianna-u.ac.jp} ; Yayoi Kagami^d ; ^{yakagami@tmig.or.jp} ; Akihito Ishigami^d ; ^{ishigami@tmig.or.jp} ; Yuichiro Tanaka^b ; ^{tanaka@marianna-u.ac.jp} ; Tomohiro Kato^a ; ^{t3kato@marianna-u.ac.jp}
• 关键词：Citrullinated proteins ; Hypoxia ; Malignant gliomas ; Peptidylarginine deiminase
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：50-56
• 全文大小：681 K
• 卷排序：482

文摘

Peptidylarginine deiminases (PADs) were induced by hypoxia in malignant glioma cells. PADs mRNA levels were up-regulated in a HIF-1-dependent manner. The induced PADs citrullinated the cell-derived proteins when tested in the lysates. Multiple proteins citrullinated by hypoxia-induced PADs were identified. An extracellular domain of VEGFR2 was citrullinated by human PAD2.