Late-occurring chromosome aberrations and global DNA methylation in hematopoietic stem/progenitor cells of CBA/CaJ mice exposed to silicon (28Si) ions
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- 作者：Kanokporn Noy Rithidecha ; kanokporn.rithidech@stonybrookmedicine.edu" class="auth_mail" title="E-mail the corresponding author ; Kanokporn.Rithidech@sbumed.org" class="auth_mail" title="E-mail the corresponding author ; Louise M. Honikela ; Paiboon Reungpathanaphonga ; b ; Montree Tungjaia ; c ; Witawat Jangiama ; d ; Elbert B. Whortone
- 关键词：Chromosome aberrations ; DNA methylation ; Hematopoietic stem/progenitor cells ; Heavy ions ; Mice
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：781
- 期：Complete
- 页码：22-31
- 全文大小：2275 K
文摘
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Late-occurring chromosome aberrations were found in HSPCs of exposed CBA/CaJ mice.
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A dose-dependent reduction in the level of global 5hmC was detected in HSPCs.
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There is a link between reduced global 5hmC levels and genomic instability in vivo.
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The level of global 5hmC is a better marker of radiation exposure than that of 5mC.