Effects of propofol on glycinergic neurotransmission in a single spinal nerve synapse preparation
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- 作者：Masahito Wakitaa ; b ; Naoki Kotanic ; Norio Akaikea ; c ; d ; akaike.n@juryo.or.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNQX ; 6-cyano-7-nitroquinoxaline-2 ; 3-dione ; Cont ; control ; D-AP5 ; D-(-)-2-amino-5-phosphonovaleric acid ; EGTA ; ethylene glycol tetraacetic acid ; eIPSC(s) ; evoked inhibitory postsynaptic current(s) ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; IGABA ; GABAA receptor-mediated whole-cell currents ; IGly ; glycine receptor-mediated whole-cell currents ; ISI ; inter-stimulus interval ; sIPSC(s) ; spontaneous inhibitory postsynaptic current(s) ; PPR ; paired-pulse ratio ; Rf ; failure rate ; SG ; sub
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：147-156
- 全文大小：1765 K
文摘
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Effects of propofol were examined at spinal cord glycinergic synapses.
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Propofol potentiated the glycine receptor-mediated whole-cell responses.
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Propofol increased the spontaneous and action-potential dependent glycine releases.
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The results suggest propofol directly act on pre- and postsynaptic side.
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All effects of propofol were seen at higher than clinically relevant concentrations.