As geophysical investigations are sensitive to contrasts in physical properties of soils, these methods can be useful to detect such targets. The specific karstic context encountered in the Tournaisis area strongly guides the choice of investigation techniques. Electrical resistivity imaging (ERI) methods were tested on a well-known site where dropout sinkholes occurred formerly. This site was also studied using static cone penetration tests (CPT) and boreholes. A 3D inverted resistivity model was computed based on the 2D ERI models obtained after inversion. Resistivity profiles were extracted at each CPT location and compared to geotechnical results to determine an empirical and site-specific resistivity law that allows discrimination between weathered zones and sound limestone. Performance tests were conducted to evaluate the potential of the proposed methodology for two typical engineering problems based on two current hypotheses. Borehole data were used as ground truth. Similar performance tests were also computed using the CPT depth to bedrock model. The results of these performance tests are compared and discussed. Finally, an ERI-based investigation strategy is proposed to assess karst hazard in palaeokarstic context, such as encountered in the Tournaisis area, at the scale needed for building and infrastructure purposes.