Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes

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• 作者：Sara Tulipani^a ; ^b ; ^{sara.tulipani@ub.edu} ; Magali Palau-Rodriguez^a ; Antonio Miñ ; arro Alonso^c ; Fernando Cardona^b ; ^f ; Anna Marco-Ramell^a ; Bozo Zonja^d ; Miren Lopez de Alda^d ; Araceli Muñ ; oz-Garach^b ; ^f ; Alejandro Sanchez-Pla^c ; ^e ; Francisco J Tinahones^b ; ^f ; Cristina Andres-Lacueva^a ; ^{candres@ub.edu}
• 关键词：HbA1c ; glycated hemoglobin ; Cer ; ceramide ; CHOL ; total cholesterol ; DLDA ; diagonal discriminant analysis ; FG ; fasting glucose ; HDL-C ; high-density lipoprotein cholesterol ; HOMA-IR ; Homeostatic Model Assessment ; LDA ; linear discriminant analysis ; LDL-C ; low-density lipoprotein cholesterol ; n.s. ; not significant ; PC ; phosphatidylcholine ; PE ; phosphatidyletanolammine ; PLSDA ; Partial least squares projection to latent structures-discriminant analysis ; PS ; phosphatidylserine ; PUFA ; polyunsaturated fa
• 刊名：Clinica Chimica Acta
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：463
• 期：Complete
• 页码：53-61
• 全文大小：859 K
• 卷排序：463

文摘

Metabolomic studies on the obesity and type 2 diabetes relationship are scarce. Decreased (lyso)glycerophospholipids significantly associated to obesity This decrease was independent from the glycemic state of the individuals Glutamate and glycine were biomarkers of early diabetes onset associated to obesity Valine (BCAA) associated to prediabetes in a BMI-independent manner