Development of bioluminescence imaging of respiratory syncytial virus (RSV) in virus-infected live mice and its use for evaluation of therapeutics and vaccines

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• 作者：Sandra Fuentes^a ; Diego Arenas^a ; Martin M. Moore^b ; Hana Golding^a ; Surender Khurana^a ; ^{Surender.Khurana@fda.hhs.gov}
• 关键词：RSV ; Vaccine ; Neutralization ; Antibody ; Palivizumab ; Live imaging. Ds-Cav1 ; F protein ; Pre-fusion F ; Animal model ; Immune complex ; Efficacy ; Therapeutic ; Treatment
• 刊名：Vaccine
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：35
• 期：4
• 页码：694-702
• 全文大小：2216 K
• 卷排序：35

文摘

An animal model of whole body live imaging for evaluating vaccines and therapeutics. This model was tested with vaccine and post exposure treatment with Palivizumab. Difference between viral loads measured by plaque assay and live imaging. Live imaging approach significantly reduces the number of animals needed.