Free fatty acid receptor 1 (FFAR1/GPR40) signaling affects insulin secretion by enhancing mitochondrial respiration during palmitate exposure
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- 作者：Hjalti Kristinsson ; Peter Bergsten ; Ernest Sargsyan ; ernest.sargsyan@mcb.uu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-DG ; 2-deoxyglucose ; BSA ; bovine serum albumin ; DAG ; diacylglycerol ; FBS ; fetal bovine serum ; FFA ; free fatty acid ; FFAR1 ; free fatty acid receptor 1 ; GL/FFA ; glycerolipid/free fatty acid ; GPCR ; G-protein coupled receptor ; GSIS ; glucose-stimulated insulin secretion ; IP3 ; inositol triphosphate ; LC-CoA ; long-chain acyl CoAs ; PIP2 ; phosphatidylinositol 4 ; 5-bisphosphate ; PKC ; protein kinase C ; PLC ; phospholipase C ; OCR ; oxygen consumption rate ; CPT1 ; carnitine palmitoyltransferase 1 ; TAG ; triacylgl
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：1853
- 期：12
- 页码：3248-3257
- 全文大小：1504 K
文摘
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Metabolic and FFAR1 pathways of fatty acids converge to enhance respiration.
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G伪q-coupled signaling enhances mitochondrial function in the presence of palmitate.
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Intracellular fatty acid metabolism promotes glucose utilization.
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Long-term palmitate exposure lowers ATP-coupling efficiency and deteriorates GSIS.
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Inhibition of FFAR1 during chronic palmitate exposure leads to elevated respiration.