Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats
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- 作者：Lin Zhaoa ; b ; 1 ; Xuan Zoua ; c ; 1 ; Zhihui Fenga ; b ; zhfeng@mail.xjtu.edu.cn" class="auth_mail ; Cheng Luoa ; b ; Jing Liua ; b ; Hao Lia ; b ; Liao Changa ; b ; Hui Wanga ; b ; Yuan Lia ; b ; Jiangang Longa ; b ; Feng Gaod ; fgao@fmmu.edu.cn" class="auth_mail ; Jiankang Liua ; b
- 关键词：SREBP1 ; Sterol regulatory element-binding protein-1 ; FAS ; Fatty acid synthase ; CPT1A ; Carnitine palmitoyltransferase IA ; CPT1B ; Carnitine palmitoyltransferase IB ; TG ; Triglyceride
- 刊名：Experimental Gerontology
- 出版年：August 2014
- 年：2014
- 卷：56
- 期：Complete
- 页码：3-12
- 全文大小：1486 K
文摘
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Lipid accumulates in aged muscle, heart and liver, but not in kidney.
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The lipid deposit is independent of lipogenesis activation.
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PGC-1伪 is decreased in muscle, heart, and liver, but not in kidney.
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Mitochondrial dynamics are disrupted in aged muscle, heart and liver except kidney.
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Autophagy was decreased in aged muscle, heart, and liver, but not in kidney