Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model
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- 作者：Gabriel J. Paveya ; f ; 1 ; Ammar T. Qureshia ; 1 ; Allison M. Tomasinoa ; Cary L. Honnoldb ; Danett K. Bishopc ; Shailesh Agarwald ; Shawn Loderd ; Benjamin Levid ; Maurizio Pacificie ; Masahiro Iwamotoe ; Benjamin K. Pottera ; f ; Thomas A. Davisa ; f ; thomas.a.davis196.ctr@mail.mil" class="auth_mail" title="E-mail the corresponding author ; Jonathan A. Forsberga ; f
- 关键词：Heterotopic ossification ; Prophylaxis ; Animal model ; Retinoic acid receptor-γ agonist ; Endochondral ossification ; Traumatic extremity injury ; Blast overpressure exposure ; Bioburden
- 刊名：Bone
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：90
- 期：Complete
- 页码：159-167
- 全文大小：1396 K
文摘
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There is a high prevalence of heterotopic ossification (HO) following traumatic and combat-related amputations.
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The retinoid signaling pathway and nuclear retinoic acid receptors (RARs) are important regulators of skeletal development and growth as well as ectopic bone.
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Palovarotene, a nuclear retinoic acid receptor γ agonist, is a potent inhibitor of chondrogenesis.
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Palovarotene suppressed post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation.
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This is the first demonstration that a retinoid agonist-based strategy could be used to counteract trauma-provoked HO.