PAMAM-pullulan conjugates as targeted gene carriers for liver cell

详细信息    查看全文

• 作者：Saeedeh Askarian^a ; ^{Askarians891@mums.ac.ir} ; Khalil Abnous^b ; ^{Abnouskh@mums.ac.ir} ; Sara Ayatollahi^c ; ^{Ayatollahis881@mums.ac.ir} ; Sara Amel Farzad^b ; ^{Amelfs1@mums.ac.ir} ; Reza Kazemi Oskuee^d ; ^{Oskueekr@mums.ac.ir} ; Mohammad Ramezani^b ; ^{Ramezanim@mums.ac.ir}
• 关键词：PAMAM dendrimer ; Pullulan ; Gene delivery ; Nanoparticle
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：929-937
• 全文大小：1852 K
• 卷排序：157

文摘

Pullulan as a linear carbohydrate was utilized as liver targeting molecules and conjugated to polyamidoamine (PAMAM). PAMAM-pullulan derivatives exhibited better transfection efficiency than the unmodified PAMAM and pullulan with reduced cytotoxicity in hepatocyte cells. Delivery of nucleic acids into the non-targeted cells was similar to unmodified PAMAM confirming the targeting property of pullulan.