Pancreatic acinar cells: Molecular insight from studies of signal-transduction using transgenic animals

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• 作者：David I. Yule
• 关键词：Pancreatic acinar cell ; Ca²⁺ signaling ; Exocytosis ; Inositol 1 ; 4 ; 5-trisphosphate receptor
• 刊名：The International Journal of Biochemistry and Cell Biology
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：42
• 期：11
• 页码：1757-1761
• 全文大小：742 K

文摘

Pancreatic acinar cells are classical exocrine gland cells. The apical regions of clusters of coupled acinar cells collectively form a lumen which constitutes the blind end of a tube created by ductal cells – a structure reminiscent of a “bunch of grapes”. When activated by neural or hormonal secretagogues, pancreatic acinar cells are stimulated to secrete a variety of proteins. These proteins are predominately inactive digestive enzyme precursors called “zymogens”. Acinar cell secretion is absolutely dependent on secretagogue-induced increases in intracellular free Ca²⁺. The increase in [Ca²⁺]_i has precise temporal and spatial characteristics as a result of the exquisite regulation of the proteins responsible for Ca²⁺ release, Ca²⁺ influx and Ca²⁺ clearance in the acinar cell. This brief review discusses recent studies in which transgenic animal models have been utilized to define in molecular detail the components of the Ca²⁺ signaling machinery which contribute to these characteristics.