Impact by pancreatic stellate cells on epithelial-mesenchymal transition and pancreatic cancer cell invasion: Adding a third dimension in vitro
详细信息 查看全文
- 作者：Emelie Karnevia ; b ; Emelie.karnevi@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Ann H. Rosendahlb ; Ann.rosendahl@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Katarzyna Said Hilmerssona ; katarzyna.said_hilmersson@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Moin A. Saleemc ; m.saleem@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Roland Anderssona ; roland.andersson@med.lu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：ECM ; extra-cellular matrix ; EMT ; epithelial-mesenchymal transition ; TAM ; tumour-associated macrophage ; TGF-β ; transforming growth factor β ; TPSC ; tumour-associated pancreatic stellate cell ; ZEB1 ; zinc finger E-box binding homeobox 1 ; ZO-1 ; zona occludens protein 1/tight junction protein 1
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：346
- 期：2
- 页码：206-215
- 全文大小：4291 K
文摘
- •
Pancreatic stellate cells stimulate EMT in pancreatic cancer cells.
- •
Pancreatic stellate cells promote single cell and cohort invasion by cancer cells.
- •
M2-like macrophages induce ECM invasion by non-invasive cancer cells.
- •
High glucose conditions enhance cancer cell invasion and changes in EMT-markers.
- •
The 3D organotypic model visualise the role of tumour microenvironment in vitro.