Key role of pancreatic stellate cells in pancreatic cancer
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- 作者：Srinivasa P. Pothulaa ; b ; Zhihong Xua ; b ; David Goldsteina ; Romano C. Pirolaa ; b ; Jeremy S. Wilsona ; b ; Minoti V. Aptea ; b ; m.apte@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic stellate cells ; Pancreatic cancer ; Stromal&ndash ; tumour interactions ; Desmoplastic reaction ; Tumour microenvironment
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：381
- 期：1
- 页码：194-200
- 全文大小：355 K
文摘
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Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma of pancreatic cancer.
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Weight of evidence to date supports a facilitatory role for PSCs in pancreatic cancer progression.
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A multipronged approach involving targeting of cancer cells and reprogramming of stroma may improve the patient outcome.