Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells

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• 作者：Yuan Seng Wu^a ; ^d ; Ivy Chung^a ; ^d ; Won Fen Wong^b ; Atsushi Masamune^c ; Maw Shin Sim^a ; Chung Yeng Looi^a ; ^{chungyeng@gmail.com}
• 关键词：Tumor microenvironment ; Cancer-associated fibroblasts ; Cytokines ; Metastasis ; Mechanism ; Pancreatic ductal adenocarcinoma
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：296-306
• 全文大小：1948 K
• 卷排序：1861

文摘

PSC-derived IL-6 promotes EMT phenotypes and gene expression in Panc-1 cells. JAK/Stat3 signaling induced by IL-6 mediates EMT and Nrf2 gene expression. Intracellular Nrf2 activity is essential for EMT phenotypes and gene expression. Simultaneous inhibition of Nrf2 and Stat3 signaling represses EMT gene expression. Targeting Stat3/Nrf2 pathway downstream of IL-6 may improve PDAC prognosis.