- 作者：Lai-Shan Tam ; MD? ; tamls_813@yahoo.com ; Qing Shang ; PhD? ; Edmund K. Li ; MD? ; Shang Wong ; PhD? ; Rui-Jie Li ; PhD? ; Ka-Lai Lee ; MRCP&dagger ; ; Ying-Ying Leung ; MRCP&Dagger ; ; King-Yee Ying ; FRCP§ ; ; Cheuk-Wan Yim ; MRCP¡Î ; Emily W. Kun ; FRCP¶ ; ; Moon-Ho Leung ; FHKCP?? ; Martin Li ; PhD? ; Tena K. Li ; BN? ; Tracy Y. Zhu ; PhD? ; Ricky K. Chui ; BEng? ; Lorraine Tseung ; BBA? ; Shui-Lian Yu ; PhD? ; Woon-Pang Kuan ; MRCP? ; Cheuk-Man Yu ; MD?
- 关键词：early RA ; sRAGE ; augmentation index ; pulse wave velocity ; intima-media thickness
- 刊名：Seminars in Arthritis and Rheumatism
- 出版年：2013
- 出版时间：February, 2013
- 年：2013
- 卷：42
- 期：4
- 页码：333-345
- 全文大小：441 K
Objective
We assessed whether a serum soluble receptor for advanced glycation end product (sRAGE) levels were associated with a progression of carotid atherosclerosis and arterial stiffness indexes in a cohort of early rheumatoid arthritis (RA) patients.Methods
RA patients with symptoms onset <2 years were recruited. Vascular assessments and serum sRAGE levels were measured at baseline and 1 year later. Arterial stiffness was determined by pulse wave velocity and aortic augmentation index (AIx). Carotid intima-media thickness was measured using high-resolution ultrasound.
Results
Ninety-four patients completed the 1-year study. Fifty-three (56.4 % ) achieved disease remission [28-joint disease activity score (DAS28 < 2.6)] at 12 months. Improvement in arterial stiffness was observed as reflected by the significant reductions in AIx and pulse wave velocity. At 12 months, the sRAGE levels increased significantly compared with baseline (939.8 ¡À 517.7 pg/ml to 1272.1 ¡À 567.3 pg/ml, P < 0.001). Changes in sRAGE levels were significantly higher in men compared to women (768 ¡À 510 pg/ml versus 271 ¡À 490 pg/ml, P < 0.05) and was negatively associated with the change in AIx (r = ?0.259, P = 0.023). Changes in sRAGE level were not associated with other demographic, clinical, cardiovascular risk factors or treatment. Using multivariate analysis, the change in sRAGE levels and baseline high-density lipoprotein were independent predictors associated with the change in AIx.
Conclusions
Arterial stiffness improved significantly in patients with early RA after effective control of inflammation. Increase in sRAGE level was associated with a decrease in AIx, suggesting that sRAGE may play an important role in the ligand-soluble receptor for advanced glycation end product interaction propagated inflammation and vascular stiffness in these patients.