From benzodiazepines to peripheral and brain steroid biosynthesis

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• 作者：Vassilios  ; Papadopoulos  ; ;   ; ^{vassilios.papadopoulos@mcgill.ca}
• 关键词：Cholesterol ; DBI ; Neurosteroids ; Peripheral-type benzodiazepine receptor
• 刊名：Pharmacological Research
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：64
• 期：4
• 页码：330-332
• 全文大小：88 K

文摘

From the biochemistry of testicular and adrenal steroids to the mysteries of brain steroid biosynthesis and from pharmacy and pharmacology to neuropharmacology and neurosciences were two transitions in my scientific career where Erminio (Mimo) Costa played a catalytic role. A review of the years and findings that contributed in our understanding of the link between benzodiazepines and neurosteroid biosynthesis that established the pharmacology of neurosteroidogenesis is a testimony to Dr. Costa's will to push the borders of knowledge that inspired us to challenge existing notions and paradigms.