Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model
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- 作者：Junya de Lacorte Singulani ; Liliana Scorzoni ; Ana Carolina Alves de Paula e Silva ; Ana Marisa Fusco-Almeida ; Maria José ; Soares Mendes-Giannini ; gianninimj@gmail.com" class="auth_mail" title="E-mail the corresponding author ; giannini@fcfar.unesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alternative animal model ; Antifungals ; Efficacy ; Paracoccidioidomycosis
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：48
- 期：3
- 页码：292-297
- 全文大小：1486 K
文摘
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Galleria mellonella is a useful model to evaluate infection by Paracoccidioides spp. and response to antifungals.
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Fungicidal and fungistatic effects of amphotericin B and itraconazole, respectively, were observed in the model.
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Antifungals did not affect the haemocyte density.
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G. mellonella can serve as a rapid model to test other isolates of Paracoccidioides and to screen new antifungals.