Infection with Paracoccidioides brasiliensis induces B-1 cell migration and activation of regulatory T cells

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• 作者：Vanessa Noal^a ; Suelen Santos^a ; Karen Spadari Ferreira^b ; Sandro Rogerio Almeida^a ; ^{sandroal@usp.br}
• 关键词：B-1 cell ; PCM ; Regulatory T cell
• 刊名：Microbes and Infection
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：12
• 页码：798-803
• 全文大小：1156 K
• 卷排序：18

文摘

Paracoccidioidomycosis is a systemic mycosis endemic to Latin America. The infection is initiated by inhalation of conidia into the lung and may develop as localized or disseminated disease depending on the depression of cellular immunity. In the present study, we observed that intratracheal infection with Paracoccidioides brasiliensis caused the percentage of resident B-1 cells to decrease. Using xid mice reconstituted with B-1 cells, we observed that B-1 cells migrate to the spleen and stimulate increases in the regulatory T cell subpopulation in response to P. brasiliensis infection. Collectively, these data demonstrate an active role for B-1 cells in susceptibility to paracoccidioidomycosis.